PME5366 Seminar (3cr.)
Presentation of one seminar and one poster required during the year as well as regular attendance at the departmental seminar series of the student’s primary program. Active participation in the annual Pathology Research Day of the Department of Pathology and Laboratory Medicine. Seminar and poster presentations will be organized by the Pathology and Experimental Medicine program and evaluated by Pathology and Experimental Medicine members. Compulsory for students enrolled in the MSc program. Graded S/NS.
PME8112 Cell Biology and the Molecular Basis of Pathological Phenotypes (3cr.)
Molecular principles of cell biology, with a focus on the mechanisms of disease. Disorders in cell biological processes that underlie many pathological phenotypes, such as intracellular transport, mitochondrial dynamics, cell biology of the nucleus and the regulation of the cytoskeleton. Emphasis on emerging experimental techniques, including functional assay design, fluorescence microscopy (multi-photon, confocal, assays like Fluorescence Resonance Energy Transfer (FRET), Fluorescence Lifetime Imaging Microscopy (FLIM), Fluorescence Recovery After Photobleaching (FRAP), photoactivation and uncaging) and electron microscopy. Participants will have hands-on experience and will work to apply these techniques to their own research problems by rotation through participating laboratories. The experiments performed by the students during the course will be assembled into a manuscript-style paper for submission at the end of the term to be graded by the course co-ordinator. Enrolment is limited to 10 students and preference will be given to students whose projects are related directly to these concepts and techniques.
PME8366 Seminar (3cr.)
Presentation of one seminar and one poster required during the year as well as regular attendance at the departmental seminar series of the student’s primary program. Active participation in the annual Pathology Research Day of the Department of Pathology and Laboratory Medicine. Seminar and poster presentations will be organized by the Pathology and Experimental Medicine program and evaluated by Pathology and Experimental Medicine members. Compulsory for students enrolled in the PhD program.
Graded S/NS.
Courses related to the collaborative program offered by each participating unit.
BCH8107 ADVANCED TOPICS IN STRUCTURE AND FUNCTION OF PLASMA LIPOPROTEINS (3cr.)
Recent advances in our knowledge of the plasma lipoproteins with a special emphasis on their role in the etiology of atherosclerosis. The subject will be introduced by an overview of the general structural properties of lipoproteins which will be followed by detailed discussion of the structure, metabolism and genetics of the apolipoproteins, the proteins and enzymes that modify lipoproteins and cell surface lipoprotein receptors. Other topics will include cholesterol homeostasis, plasma cholesterol transport and disorders of lipoprotein metabolism.
CMM5001 THE PATHOLOGICAL BASIS OF DISEASE (3cr.)
Introductory Course for Non-Medial Graduate Students in the Life Sciences. This course will consist of a brief introduction to pathology describing the manifestation of disease at the macroscopic and microscopic level. This will be followed by (i) A description of various types of microscopy and methodology. (ii) Concepts in flow cytometry, tissue/cell fractionation. (iii) Histo-/cytochemistry and immunohisto-/cytochemistry. (iv) Normal cells and tissues. (v) Organs. (vi) The general pathology of cells and tissues including hypertrophy, aplasia, atrophy, hyperplasia, metaplasia, dysplasia, neoplasia, storage diseases, extracellular space pathologies, necrosis and apoptosis. Blood vessel and cardiac pathologies will be covered as well as concepts in neuropathology, organ/system specific pathologies and genetic diseases.
CMM5105 INTRODUCTION TO CANCER BIOLOGY (3cr.)
An introduction to the biology of cancer. Major topics in cancer biology include the following: tumor suppression/oncogenes; apoptosis in cancer; cell immortalization and senesence; genomic instability; multistep tumorigenesis/inflammation in cancer; biology of angiogenesis; rational therapies.
CMM5315 CELLULAR AND MOLECULAR BASIS OF CARDIOVASCULAR FUNCTION/DYSFUNCTION (3cr.)
Mechanism of failing heart and cardiovascular system, its associated functions and associated conditions. Therapies for restoring function. Topics include: regulation of heart development, cell signaling, cellular and molecular mechanisms of atherosclerosis and heart disease, hormonal regulation, hypertension, bioenergetics, cardiovascular genomics and genetics, cell therapy, and regenerative medicine.
CMM8105 ADVANCED TOPICS IN CANCER BIOLOGY (3cr.)
Advanced study of recent developments in the field of cancer biology with emphasis on cellular and molecular aspects. Specific topics to be covered include: angiogenesis, apoptosis, cancer genetics, cell signaling, genetic instability, oncogenes and tumour suppressors.
NSC8101 ADVANCED TOPICS IN NEUROPATHOLOGY (3cr.)
General histopathological responses of central and peripheral nervous tissue to pathological stimuli including hypoxic-ischemic, traumatic, inflammatory/infectious, demyelinating and toxic. Emerging topics in neurology and neuropathology including the following: the pathology and pathogenesis of protein-based neurodegenerative disorders, the emerging family of RNA-mediated neurological disorders, mendelian and non-mendelian genetic diseases of the nervous system (including the role of microRNA in neurological disease), advances in diseases of skeletal muscle, advances in the molecular pathogenesis of Central Nervous System tumours, and advances in metabolic/mitochondrial/storage diseases.