Tous les cours ne sont pas nécessairement offerts chaque année. Les cours sont offerts dans la langue dans laquelle ils sont décrits.
Not all of the listed courses are given each year. The course is offered in the language in which it is described.
EDU5699 ÉVALUATION DE PROGRAMMES (3cr.)
Étude des notions de base sur la conception et la gestion de programmes. Analyse des aspects théoriques et pratiques de l'évaluation des programmes. Examens des modèles d’évaluation, de la planification du projet d’évaluation, de la rédaction du rapport d’évaluation et de la méta-évaluation.
EPI5126 INTRODUCTION TO HEALTHCARE EPIDEMIOLOGY (3cr.)
Applications of epidemiologic and statistical methods within the healthcare setting; issues specific to infection control; roles and administration of infection control, risk management and quality assurance within healthcare facilities; surveillance mechanisms for nosocomial infections; outbreak investigation methods; infection risks in special populations and settings; prevention and risk management of adverse outcomes; regulatory guidelines and accreditation; emerging issues in infection control.
EPI5142 HEALTH SERVICES EVALUATION (3cr.)
The theory and practice of health services evaluation, including specification of objectives, research designs, measures of process and outcome, and practical problems in conducting evaluations. The focus is on scientific (research) evaluation, but other evaluation strategies and techniques are discussed. Lectures and student presentations. Prerequisite: EPI 5240 or equivalent and permission of the program director.
EPI5143 EPIDEMIOLOGICAL RESEARCH USING LARGE DATABASES (3cr.)
A practical approach to using administrative and other large databases for epidemiological research. Basic and advanced statistical techniques to manipulate, link, and examine datasets; large health surveys; coding systems; data warehouses; data mining; birth and death registries; use of census data; linking postal codes to geographical files; geographical information systems. Extensive use of SAS as the primary application package. Prerequisite: Permission of the program director.
EPI5180 INTERNATIONAL HEALTH AND DEVELOPMENT (3cr.)
Presentations and seminars on philosophy of international development, international health and demographics, determinants of health, international health and human rights and humanitarian emergencies, tropical diseases and emerging pathogens, aboriginal health issues, impact of new health technologies on international health, cross cultural communication, management methods for international health. Seminar presentation required. Prerequisite: Permission of the program director.
EPI5181 POPULATION HEALTH RISK ASSESSMENT I (3cr.)
National and international policy frameworks for health risk assessment and management, including determinants of population health; epidemiological, clinical, and toxicological methods for identifying health hazards; population health surveillance; methods of population health risk assessment; regulatory, economic, advisory, and technological approaches to population health risk management; community action and social marketing; selection of risk management strategies; risk perception and risk communication. Lectures and case studies. Preparation of term paper on a current issue in population health risk assessment. Co-requisites: EPI 5240 and EPI 5242 or equivalents. Exclusion: PHR 5181. Prerequisite: Permission of the program director.
EPI5182 SAMPLE SURVEY RESEARCH METHODS (3cr.)
Comprehensive review of the use of sample surveys in epidemiologic research. Sampling designs and methods. Simple random samples and stratified samples. Multi-stage sampling. Other complex survey designs. Cluster sampling and sample weights. Response and non-response biases. Questionnaire design. Analysis of survey data. Ethics in surveys. Practical issues in surveys. Pre-requisite: Basic understanding of statistical methods and epidemiologic principles.
EPI5183 APPROACHES TO COMMUNITY/PUBLIC HEALTH PROGRAM EVALUATION (3cr.)
Critical review and practical application, in collaboration with a health care community partner, of approaches to community and public health program evaluation. Community partners include representatives of the community agencies whose mandate or remit includes evaluation of their community/public health program(s). Evaluation based on student’s ability to (a) identify most appropriate approaches to evaluation, (b) critically review strengths and limitations of chosen approaches , (c) apply the selected approach appropriately to examine and quantify impact of the program(s).
EPI5188 HEALTH TECHNOLOGY ASSESSMENT (3cr.)
Definition and scope of health technology assessment; needs assessment; practice variations; use of administrative databases; evaluation of diagnostic tests; development and use of practice guidelines and clinical prediction rules; health technology assessment in the developing world. Lectures, seminars and case studies. Prerequisite: Permission of the program director.
EPI5189 HEALTH ECONOMIC EVALUATION (3cr.)
Brief overview of economics and health economics; examination of analyses used in epidemiologic and clinical research: cost-effectiveness analysis, cost-minimization analysis, cost-utility analysis (including determination of utilities), cost-benefit analysis, cost of illness studies and use of economic methods in priority-setting. Lectures and seminars. Written report required, presenting an economic evaluation or a detailed review of the economic literature in a particular area. Prerequisite: Permission of the program director.
EPI5210 PUBLIC HEALTH ADMINISTRATION (3cr.)
Introduction to practical aspects of managing a health unit from the viewpoint of a Medical Officer of Health. The organization of public health services, relationships with the Board, leadership and management, budgeting and human resource issues including labour relations. Problem-based approach in a seminar format. Prerequisite: Permission of the program director.
EPI5212 COMMUNICABLE DISEASE EPIDEMIOLOGY (3cr.)
Consideration of the specialized methods used in the investigation and control of communicable disease. Detailed review of the epidemiology of the major communicable diseases. Lectures, presentations by invited experts, and student presentations. Prerequisite: A basic knowledge of epidemiologic methods and permission of the program director.
EPI5213 CHRONIC DISEASE EPIDEMIOLOGY (3cr.)
Review of the descriptive epidemiology (distribution, trends, risk factors) of the major chronic diseases, with emphasis on circulatory diseases, cancer, injuries, and mental health problems. Approaches to primary and secondary prevention. Lectures, presentations by invited experts, and student presentations. Prerequisite: Permission of the program director.
EPI5240 EPIDEMIOLOGY I - INTRODUCTORY EPIDEMIOLOGY (3cr.)
An overview of epidemiology - uses, methods, and data sources. Descriptive and analytical epidemiology. Lectures and assignments in which students will work with data and will gain experience in critically reviewing epidemiologic literature. Prerequisites: EPI 5242 (Biostatistics I) or equivalent; may be taken concurrently with the permission of the program director.
EPI5241 EPIDEMIOLOGY II - ADVANCED EPIDEMIOLOGY (3cr.)
This second level epidemiology course covers major principles of design, analysis, and interpretation of epidemiologic research. Material presented in a quantitative manner. Prerequisites: EPI 5240 (Epidemiology I) and EPI 6276 (Quantitative Methods in Epidemiology); EPI 6276 may be taken concurrently with the permission of the program director.
EPI5242 BIOSTATISTICS I (3cr.)
Building on the students' prior background in statistics, this course explores the use of mathematical models in statistical data analysis. Topics include analysis of categorical data, choice of linear vs non-linear models, estimation of parameters, testing of hypotheses by parametric and non-parametric methods, analysis of variance, linear and logistic regression models, introduction to survival analysis. This course may also be offered in French: EPI 5642. Prerequisite: Basic course in Statistics and permission of the program director.
EPI5243 GUIDED RESEARCH PROJECTS (3cr.)
Practical experience of the application of epidemiologic methods. The student will participate in one or more research projects underway in the Department, and will gain experience in the day-to-day management of the project, in data collection, in data analysis and report preparation.
EPI5244 SPECIAL TOPICS IN EPIDEMIOLOGY (3cr.)
The content of this seminar course is flexible, covering issues of current debate in communicable and non-communicable disease epidemiology: Presentations by participants and invited experts and seminar discussion. Prerequisites: EPI 5240 and EPI 5242 and permission of the program director.
EPI5251 MEASUREMENT IN HEALTH (3cr.)
An overview of measurement theory as applied to health measurement; a review of existing measurements of health status in clinical and research applications, plus practical experience of how to develop and test new measurement methods. Prerequisite: Permission of the program director.
EPI5271 HEALTH PROMOTION (3cr.)
Origins, theories and techniques of health promotion at the individual and community levels. Examination of current health promotion activities in Canada and elsewhere. Prerequisite: Permission of the program director.
EPI5281 DEVELOPMENTS IN EPIDEMIOLOGY (3cr.)
Major new developments in epidemiology, conceptualization of research topics and objectives for the thesis. Critical appraisal of current and classical literature in epidemiology. Seminars on current topics. Prerequisite: Permission of the program director.
EPI5330 VITAL AND HEALTH STATISTICS AND DEMOGRAPHY (3cr.)
Techniques of demography, health and vital statistics with particular reference to health care and epidemiologic research. The Canadian demographic structure and trends, vital registration procedures, calculation and interpretation of vital rates, life table analysis and record linkage. Lectures and exercises. Prerequisite: Permission of the program director.
EPI5340 EPIDEMIOLOGICAL METHODS (1,5cr.)
Major principles of study design and analysis: validity in epidemiologic studies; precision and statistics in epidemiology studies; confounding; additive and multiplicative interaction; stratified analysis; regression models; regression modeling; bias analysis; analytical strategy. Prerequisites: EPI 5240 and EPI 5242
EPI5341 EPIDEMIOLOGICAL APPLICATIONS (1,5cr.)
Interpretation of epidemiologic research and some specific topics: complex survey data analysis; attributable risk, odds ratio and relative risk estimation in multivariate analysis; combined effect of multiple exposures and interaction measures; chronic disease screening and surveillance; environmental epidemiology. Prerequisite: EPI5340
EPI5342 GENETIC EPIDEMIOLOGY (1,5cr.)
Scope of genetic epidemiology, including an overview of types of human genetic variation, approaches to gene discovery vs. gene characterization. Specific issues include: assessment of effect of family history on disease risk; measurement of genetic variation, genotyping errors and factors affecting these; study designs specially adapted to genetic epidemiology – family based designs (e.g. case-parent trio, case-sib designs), case-only designs; candidate gene and genome-wide association approaches to genetic association; gene-environment and gene-gene interaction; Integration of evidence; evaluation of potential value of genetic information in screening (e.g. newborn screening), family history tools and genetic testing. Prerequisite: EPI5340
EPI5343 OUTCOME MEASURES IN HEALTH RESEARCH (1,5cr.)
Technical review of the design requirements for outcome measures in health research and clinical trials; a historical review of the evolution of such measures and a survey of the quality of existing instruments in various fields of health research (disability, quality of life, mental health, pain, etc.). This course is designed for students who will need to use and interpret health measures in their research. Prerequisite: EPI5340
EPI5344 SURVIVAL ANALYSIS IN THE HEALTH SCIENCES (1,5cr.)
Exploration of methods for the analysis of data which includes information about the time when an event occurred. Non-regression methods of analyzing survival data, including actuarial life tables, the Kaplan-Meier method, the log-rank test, and person-time. The hazard curve and its links to incidence rate/density. Proportional hazards regression modelling (Cox modelling) including interpretation of model parameters, model building strategies and assessing the fit of the model. Methods to handle time varying covariates and non-proportional hazards will be discussed. Classes will include hands-on modeling examples using SAS statistical software. Prerequisite: EPI5340
EPI5345 APPLIED LOGISTIC REGRESSION (1,5cr.)
Foundation of model estimation: maximum likelihood; modeling dichotomous outcome (dependent) variables: logistic regression; logistic models with several independent variables; interpretation of model parameters; model-building strategies; assessing the fit of the model; regression diagnostics. Classes will include hands-on modeling examples using SAS statistical software. Prerequisite: EPI5340
EPI5346 APPLIED LONGITUDINAL AND CLUSTERED DATA ANALYSIS (1,5cr.)
Introduction to longitudinal (repeated measures) and clustered data and overview of regression models for correlated data; linear mixed effects models: modelling the mean; modelling the covariance structure; generalized estimating equations and generalized linear mixed effects models; regression diagnostics; missing data and drop-out; case studies. Classes will include hands-on modeling examples using SAS statistical software. Prerequisite: EPI5340
EPI5642 BIOSTATISTIQUE I (3cr.)
En misant sur les connaissances préalables en statistique des étudiants, ce cours examine l'application des modèles mathématiques dans l'analyse de données statistiques. Parmi les sujets à traiter : analyse de données catégoriques, choix de modèles linéaires ou non linéaires, estimation des paramètres, tests d'hypothèses par méthodes paramétriques ou non paramétriques, analyse de la variance, modèles de régression linéaire et logistique, et introduction à l'analyse de survie. Également offert en anglais : EPI 5242. Préalable: Cours de base en statistiques et permission du responsable du programme.
EPI6126 ADVANCED HEALTHCARE EPIDEMIOLOGY (3cr.)
Exploration of advanced healthcare epidemiology topics including pandemic planning, emergency preparedness, environmental considerations, healthcare surveillance techniques, quality improvement and patient safety initiatives, antimicrobial control programs, blood safety, developing and delivering educational programs, healthcare organization and administration, healthcare epidemiology research design. Lectures, presentations by invited experts, workshops and student presentations. Pre-requisites: EPI 5240, EPI 5126.
EPI6178 INTERVENTION STUDIES IN HEALTH RESEARCH (3cr.)
Practical introduction to intervention studies in the health field, including experimental and quasi-experimental studies and clinical and community trials. Question formulation; conduct of literature reviews; design issues (choice of research design and study population, implications for validity of results); ethical issues; instrument development; data collection and management; approach to data analysis; report writing and presentation. Examples drawn from both population and clinical research. Development and presentation of proposal for an intervention study. Prerequisite: Permission of the program director.
EPI6179 COMPUTER APPLICATIONS IN MEDICINE (3cr.)
A laboratory course introducing health researchers to packaged computer programs for data analysis. Applications of these programs to the participants' own research, the organization of large data files and the choice between different types of computers. Prerequisite: Permission of the program director.
EPI6181 SOCIAL ASPECTS OF EPIDEMIOLOGY (3cr.)
This course will analyze the way in which behavioural, social and emotional forces influence patterns of disease. The links between these processes and physiological changes; inferences on how best to intervene to modify "lifestyle" risk factors; recent prevention and health promotion trials will be reviewed. May also be offered in French: EPI 6581. Prerequisite: Permission of the program director.
EPI6182 POPULATION HEALTH RISK ASSESSMENT II (3cr.)
Scientific methods for population health risk assessment; characterization of population health risks, and attendant uncertainties; risk modeling; combining risk information from different sources; risk acceptability; principles of risk management decision making; evidence-based risk management policy development; audit and evaluation of risk interventions; priority setting; case studies on current population health risk assessment issues. Term paper on a current methodological issue in population health risk assessment required.Exclusion: PHR 6182. Prerequisites: EPI 5240, EPI 5242, and EPI 5181, or equivalents and permission of the program director.
EPI6188 SYSTEMATIC REVIEWS AND META-ANALYSIS (3cr.)
Approaches to the systematic review of evidence in the health sciences. Searching for the evidence, selection of studies, quality and validity of included studies, heterogeneity, statistical analysis and other quantitative and qualitative methods. Students will be required to do a meta-analysis on a topic of their own interest. Prerequisites: EPI 5240 and EPI 5242 and permission of the program director.
EPI6189 CLINICAL DECISION MAKING (3cr.)
Theories of decision making and their validity in health care applications. Comparison of decision support methods: decision analysis, utility assessment techniques, patient aids, practice guidelines, care maps. Methods for developing, evaluating, and disseminating decision support tools in clinical practice. Prerequisites: EPI 5240 and EPI 5242 and permission of the program director.
EPI6276 QUANTITATIVE METHODS IN EPIDEMIOLOGY (3cr.)
Application of advanced topics in statistical methods for epidemiologic data analysis: logistic regression and discriminant analysis, Poisson regression, contingency table analysis (including log-linear modelling), time series, survival analysis, Cox regression with and without time-dependent covariates, principle components and factor analysis. Prerequisites: EPI 5240 and EPI 5242 and permission of the program director.
EPI6277 BIOSTATISTICS II (3cr.)
Focus on the statistical analysis of more than one variable and/or more than two groups. Topics covered include the analysis of variance, multiple linear regression and multivariate analysis topics such as the linear discriminant analysis. Statistical analysis relevant to clinical medicine will be discussed in detail with relevant examples from clinical research papers. Prerequisite: EPI 5242 or equivalent and permission of the program director.
EPI6278 ADVANCED CLINICAL TRIALS (3cr.)
Lectures and laboratories on the detailed principles, design, methodology and statistical techniques associated with clinical trials. Emphasis on emerging topics and procedures. Prerequisites: EPI 5242 and EPI 6178 and permission of the program director.
EPI6282 SPECIAL TOPICS IN COMMUNITY MEDICINE (3cr.)
Current Community Health topics will be reviewed. Weekly seminars, written assignments, discussions, research meetings and presentations by students and invited speakers. Each student must present two seminars. Prerequisite: Permission of the program director.
EPI6283 PHARMACOEPIDEMIOLOGY (3cr.)
Issues in and methodology of pharmacoepidemiology. Discussion on the biases and confounders possible at every stage of a pharmacoepidemiological study, in drug utilization review, drug effectiveness, risk/benefit assessment and other topics. This course will normally be given every second year. Prerequisites: EPI 5240 or equivalent and permission of the program director.
EPI6344 CURRENT ISSUES IN EPIDEMIOLOGY (1,5cr.)
Topics will be selected based on student and faculty interests. Depending on the topics, the course may be given as formal lectures or in seminar format with presentations by participants and invited experts followed by in-class discussion. Prerequisites: EPI 5240 and EPI 5242 or permission of the program director.
EPI6581 INTRODUCTION À L'ÉPIDÉMIOLOGIE SOCIALE (3cr.)
Analyse de l'influence des forces sociales et du comportement humain sur le développement de la maladie. L'interaction entre le comportement et les systèmes physiologique et endocrinien, y compris le processus psychosomatique. Les indications pour l'intervention préventive par la modification du mode de vie. Également offert en anglais : EPI 6181. Préalable: Permission du responsable du programme.
Cours de doctorat / PhD Courses
EPI7101 GENETIC EPIDEMIOLOGY (3cr.)
Application of genetic biological methods to epidemiological research. Covers the development of research hypotheses; genetic determinants and gene-environment interactions; biomarkers for exposure and outcome as well as for predicting prognosis. Students will undertake a course project to design a genetic epidemiological study. Prerequisite: EPI5240 or equivalent.
EPI7102 DATA ANALYSIS METHODS IN GENETIC EPIDEMIOLOGY (3cr.)
Data analysis methods in genetic epidemiology and gene identification. Topics include the relationship between design and analysis; genetic models; methods for case-unrelated control studies, case-familial control studies and other familial designs; introduction to frequentist multiple testing and empirical Bayes methods, focus on applications to genome-wide association studies. Basic approaches in bioinformatics; insights into gene function based on the characterization of three major categories of cellular components (genome, transcriptome and proteome) and their interactions; public molecular databases. Practical lab sessions, both on statistical analysis and integration of discovery with information on gene function (commonly used algorithms; hands-on practice with data retrieval, manipulation and analysis). Prerequisite: EPI5242 or equivalent.
EPI7103 GENETIC ASSOCIATION STUDIES (3cr.)
Population-based family studies, case-control and case-family control designs and analysis. Topics include population-based family studies; case-unrelated control design and variants; case-family control designs (including case-parent trios, e.g. maternal versus paternal versus fetal genetic effects; mitochondrial DNA; imprinting); genome-wide association; linkage disequilibrium; genotyping error; imputation; population stratification and methods for its control; genotyping errors; modeling haplotype variation; Hardy-Weinberg equilibrium; replication; selection of participants, rationale for choice of genes and variants; treatment effects in studying quantitative traits; relatedness of participants; reporting of descriptive and outcome data; issues of data volume; joint effects of genes and environmental factors; epistasis; bioinformatics; causal inference. Prerequisite: EPI5242 or equivalent.
EPI7104 ADVANCED METHODS IN BIOSTATISTICS: ANALYSIS OF VARIANCE (3cr.)
Exploration of the theoretical foundations of the advanced methods in biostatistics as well as of the practical application and interpretation of these methods. Topics include repeated measures ANOVA; multivariate analysis of variance (MANOVA); split-plot ANOVA (SPANOVA); expected mean squares; randomization theory; estimation of variance using regression; tests of hypotheses for balanced and unbalanced data sets. Prerequisite: EPI5242 or equivalent.
EPI7105 ADVANCED METHODS IN BIOSTATISTICS: STATISTICAL INFERENCE (3cr.)
Advanced methods in biostatistics and probability modeling. Sample topics include: Bayesian parameter estimation; construction and use of likelihoods; hypothesis testing; comparison of inference methods using jackknife, bootstrap and normal approximations. Prerequisite: EPI5242 or equivalent.
EPI7106 QUALITATIVE RESEARCH METHODS IN EPIDEMIOLOGY (3cr.)
Theoretical frameworks and corresponding methods of qualitative research applied to epidemiological research. Topics will include: theoretical paradigms of qualitative research; matching qualitative research to types of research questions; sampling objectives and procedures; methods of data collection; analysis and interpretation; quality criteria for evaluating qualitative research studies; ethical issues and responsibilities of qualitative researchers. Relationship between qualitative and quantitative research will be explored. Prerequisite: EPI5240 or equivalent.
EPI7107 DESCRIPTIVE EPIDEMIOLOGY (3cr.)
Issues of current debate in Descriptive Epidemiology and epidemiological methods. Topics will include methods for studying the distribution of health conditions and their predictors in populations, current issues and principles of disease classification and surveillance, surveillance of prognostic factors, applying principles of demography in epidemiologic research. Prerequisite: EPI5240 or equivalent.
EPI7108 ANALYTIC EPIDEMIOLOGY (3cr.)
Issues of current debate in Analytic Epidemiology and epidemiological methods. Topics will include theory and methods in the study of the etiology of health conditions and prognostic factors, current theories of disease causation, application of causal models to epidemiologic questions, implications for study design and analysis, measurement error. Prerequisite: EPI5240 or equivalent.
EPI7109 CLINICAL AND APPLIED EPIDEMIOLOGY (3cr.)
Issues of current debate in Clinical and Applied Epidemiology and epidemiological methods. Topics will include clinical health interventions related to individual patient care; research related to the design and delivery of broader health systems and services; current analytical methods and population-based studies; decision rules; randomized clinical trials; diagnostic tests; interventions that are relevant to public health practice. Prerequisite: EPI5240 or equivalent.
EPI7111 BIOSTATISTICS III (3cr.)
Advanced methods in biostatistics, with emphasis on one or two major methods. Examination of the theoretical foundations of the methods as well as of their practical application and interpretation. Topics include multivariate statistics, longitudinal data analysis, multi-level models, and statistical genetics. Pre-requisite: EPI5242 or equivalent.
EPI7113 SPECIAL TOPICS IN EPIDEMIOLOGY II (3cr.)
Variable topics depending on the interests of students and faculty.
EPI7184 HEALTH POLICY (3cr.)
Exploration of key issues relating to health policy within and outside Canada. Topics covered: rationale for public provision and funding of health care in Canada; historical and current perspectives regarding structure and process of the Canadian health care system; specific micro and macro policy issues relating to health and health care provision (Canadian and international).
EPI7302 OBSERVATIONAL DESIGNS (1,5cr.)
Examination of the case-control method from conceptual, practical and analytical perspectives. Potential biases of different approaches. Role of nested case-control studies. Case-cohort, case-based, case-only and case-crossover designs. Implications of sampling methods for analytical approaches. Analysis of sample data sets, using SAS or STATA. The relationship between quantitative and qualitative research. Prerequisite: EPI5242 or equivalent.
EPI7303 TRANSLATION OF GENETIC DISCOVERIES FROM THE RESEARCH LABORATORY TO THE HEALTH CARE SYSTEM (1,5cr.)
Overview of the process of transferring genetic discoveries into medicine and public health, focusing primarily on chronic diseases. Topics include basic concepts and existing knowledge translational pathways and frameworks. Interdisciplinary approaches to knowledge translation, including clinical trials, guideline development, dissemination research, outcomes research, and health policy research. Using chronic disease examples to illustrate the process, students will learn which elements need to be considered at each step in the translation process. Prerequisite: EPI5240 or equivalent.
EPI7501 ÉPIDÉMIOLOGIE GÉNÉTIQUE (3cr.)
Étude de l’application de méthodes de la biologie génétique à la recherche épidémiologique. Élaboration d’hypothèses de recherche; déterminants génétiques et interactions entre facteurs génétiques et environnementaux; utilisation de biomarqueurs pour la mesure d’une exposition et de son résultat ainsi que pour l’établissement d’un pronostic. Réalisation d’un projet d’étude d’épidémiologie génétique. Préalable : EPI5240 ou l’équivalent.
EPI7502 MÉTHODES D’ANALYSE DE DONNÉES EN ÉPIDÉMIOLOGIE GÉNÉTIQUE (3cr.)
Aperçu de méthodes d’analyse des données en épidémiologie génétique et pour l’identification de gènes. Sujets abordés : relation entre protocole et analyse; modèles génétiques; méthodes d’études avec cas témoins non apparentés, d’études avec cas témoins appartenant à la famille, ainsi que d’autres protocoles familiaux; introduction aux tests multiples fréquentistes et aux méthodes bayésiennes empiriques, en mettant l’accent sur des applications à des études d’association pangénomique. Méthodes de base de la bioinformatique; aperçu de la fonction des gènes à partir de la caractérisation de trois catégories principales de composantes cellulaires (génome, transcriptome et protéome) et de leurs interactions; bases de données moléculaires publiques. Séances pratiques de laboratoire, tant sur l’analyse statistique que sur l’intégration de découvertes et de l’information sur la fonction de gènes (algorithmes communément utilisés; travaux pratiques d’extraction, de traitement et d’analyse de données). Préalable : EPI5242 ou l’équivalent.
EPI7503 ÉTUDES D’ASSOCIATION EN GÉNÉTIQUE (3cr.)
Examen approfondi d’études familiales de population, d’études cas témoins et de protocoles avec cas témoins appartenant à la famille, ainsi que de l’analyse des données correspondantes. Sujets abordés : études familiales de population; protocoles avec cas témoins non apparentés et leurs variantes; protocoles avec cas témoins appartenant à la famille (dont des trios formés d’un sujet et de ses parents, p. ex. effets génétiques maternels, paternels et fœtaux; ADN mitochondrial; empreinte); études d’association pangénomique; déséquilibre de liaison; imputation; stratification d’une population et méthodes de contrôle de la stratification; erreurs de génotypage; modélisation des variantes d’un haplotype; équilibre de Hardy-Weinberg; réplication; sélection de participants, justification du choix de gènes et de variantes; effets d’un traitement sur l’étude de traits quantitatifs; liens entre participants; compte rendu de données descriptives et de résultats; problèmes liés à la quantité de données; effets conjoints de facteurs génétiques et environnementaux; épistasie; bioinformatique; inférence causale. Préalable : EPI5242 ou l’équivalent.
EPI7504 MÉTHODES AVANCÉES DE BIOSTATISTIQUE : ANALYSE DE VARIANCE (3cr.)
Exploration des fondements théoriques des méthodes avancées de biostatistique ainsi que des applications pratiques et de l’interprétation de ces méthodes. Sujets abordés : analyse de la variance de mesures répétées; analyse de variance multidimensionnelle; analyse de variance avec subdivision de parcelles; valeurs quadratiques moyennes prévues; théorie de randomisation; estimation de la variance à l’aide d’une régression; tests d’hypothèses sur des jeux de données équilibrés et non équilibrés. Préalable : EPI5242 ou l’équivalent.
EPI7505 MÉTHODES AVANCÉES DE BIOSTATISTIQUE : INFÉRENCE STATISTIQUE (3cr.)
Méthodes avancées de biostatistique et de modélisation probabiliste. Exemples de sujets abordés : estimation bayésienne de paramètres; construction et utilisation de vraisemblances; tests d’hypothèses; comparaison de méthodes d’inférence à l’aide de la technique du ré-échantillonnage « jackknife », d’une amorce et d’approximations normales. Préalable : EPI5242 ou l’équivalent.
EPI7506 MÉTHODES DE RECHERCHE QUALITATIVE EN ÉPIDÉMIOLOGIE (3cr.)
Cadres théoriques et méthodes correspondantes de recherche qualitative appliquées à la recherche en épidémiologie. Sujets abordés : paradigmes théoriques de la recherche qualitative; recherche qualitative adaptée à divers types de questions; objectifs et procédures d’échantillonnage; méthodes de collecte, d’analyse et d’interprétation de données; critères de qualité pour l’évaluation d’une recherche qualitative; questions d’éthique et responsabilités des chercheurs en matière de recherche qualitative. Relations entre recherche qualitative et recherche quantitative. Préalable : EPI5240 ou l’équivalent.
EPI7507 ÉPIDÉMIOLOGIE DESCRIPTIVE (3cr.)
Questions actuellement débattues en épidémiologie descriptive et à propos des méthodes de l’épidémiologie. Sujets abordés : méthodes d’étude de la répartition de diverses affections et de leurs prédicteurs dans une population; problèmes actuels et principes de la classification et de la surveillance des maladies; surveillance de facteurs de pronostic; applications des principes de la démographie à la recherche en épidémiologie. Préalable : EPI5240 ou l’équivalent.
EPI7508 ÉPIDÉMIOLOGIE ANALYTIQUE (3cr.)
Questions actuellement débattues en épidémiologie analytique et à propos des méthodes de l’épidémiologie. Sujets abordés : théorie et méthodes de l’étude de l’étiologie des affections et de leurs facteurs de pronostic; théories actuelles sur les causes des maladies; application de modèles de causalité à des questions d’épidémiologie; conséquences sur la conception de protocoles, l’analyse de données et les erreurs de mesure. Préalable : EPI5240 ou l’équivalent.
EPI7509 ÉPIDÉMIOLOGIE CLINIQUE ET APPLIQUÉE (3cr.)
Questions actuellement débattues en épidémiologie clinique et appliquée, ainsi qu’à propos des méthodes de l’épidémiologie. Sujets abordés : interventions cliniques liées aux soins aux patients particuliers; recherche liée à la conception et à la prestation de systèmes et services élargis de soins de santé; méthodes analytiques actuelles et études de population; règles de décision; essais cliniques aléatoires; tests diagnostiques; interventions pertinentes en matière de santé publique. Préalable : EPI5240 ou l’équivalent.
EPI7511 BIOSTATISTIQUE III (3cr.)
Méthodes avancées de biostatistique, avec accent sur une ou deux méthodes importantes. Examen des fondements théoriques de ces méthodes ainsi que de leurs applications pratiques et de leur interprétation. Sujets abordés : statistiques multidimensionnelles, analyse de données longitudinales, modèles multi-niveaux, génétique statistique. Préalable : EPI5242 ou l’équivalent.
EPI7513 SUJETS PARTICULIERS EN ÉPIDÉMIOLOGIE II (3cr.)
Divers sujets choisis en fonction des intérêts des étudiants et du professeur.
EPI7702 ÉTUDES D’OBSERVATION (1,5cr.)
Examen de la méthode des cas témoins sur les plans conceptuel, pratique et analytique. Biais potentiel de différentes approches. Rôle d’études cas témoins imbriquées. Étude cas-cohorte, étude avec l’échantillonnage liée aux cas, protocole limité aux cas et protocole croisé. Conséquences des méthodes d’échantillonnage sur les méthodes d’analyse. Analyse d’échantillons de données à l’aide de SAS ou de STATA. Relations entre recherche qualitative et recherche quantitative. Préalable : EPI5242 ou l’équivalent.
EPI7703 LES DÉCOUVERTES EN GÉNÉTIQUE : DU LABORATOIRE DE RECHERCHE AU SYSTÈME DE SOINS DE SANTÉ (1,5cr.)
Aperçu du processus de transfert des découvertes en génétique vers les domaines de la médecine et de la santé publique, en mettant principalement l’accent sur les maladies chroniques. Sujets abordés : voies et cadres de transfert de notions fondamentales et de connaissances existantes. Approches multidisciplinaires du transfert de connaissances : essais cliniques, élaboration de lignes directrices, recherche en matière de transmission, d’évolution et de politiques de santé. À partir d’exemples portant sur des maladies chroniques, les étudiants apprendront quels éléments doivent être pris en considération à chaque étape du processus de transfert de connaissances. Préalable : EPI5240 ou l’équivalent.
EPI7910 ÉTUDES DIRIGÉES EN ÉPIDÉMIOLOGIE / DIRECTED STUDIES IN EPIDEMIOLOGY (3cr.)
Étude approfondie d’un sujet d’intérêt particulier pour l’étudiant, sous la direction d’un professeur membre du programme. Préalables : EPI5240 ou l’équivalent et approbation du Comité des études doctorales/Directed Studies on a topic of individual interest to the student under the direction of a faculty supervisor. Students planning to take this course must have the proposed content, learning activities and evaluation methods approved by the Doctoral Studies Committee. Prerequisite: EPI5240 or equivalent.
EPI7912 ÉTUDES DIRIGÉES EN BIOSTATISTIQUE / DIRECTED STUDIES IN BIOSTATISTICS (3cr.)
Étude approfondie d’un sujet en biostatistique d’intérêt particulier pour l’étudiant, sous la direction d’un professeur membre du programme. Préalables : EPI5242 ou l’équivalent et approbation du Comité des études doctorales. / In-depth study on a topic in biostatistics of individual interest to the student under the direction of a faculty member in the program. Prerequisites: EPI5242 or equivalent and permission of the Doctoral Studies Committee.
EPI7913 THÈMES SPÉCIAUX EN ÉPIDÉMIOLOGIE / SPECIAL TOPICS IN EPIDEMIOLOGY (3cr.)
Sujets variables selon les intérêts des étudiants et du corps professoral. / Variable topics depending on the interests of students and faculty.
EPI7980 STAGE / INTERNSHIP
Expérience pratique et exécution d'un projet ayant trait à l'évaluation des technologies de la santé dans un organisme de recherche ou une agence d'évaluation des technologies de la santé, sous la supervision d'un membre du corps professoral. Noté S/NS à partir d'un rapport de stage écrit et des résultats du stage. / Practical experience and completion of a project related to HTA in a research organization or an HTA agency, under the supervision of a faculty member. Graded S/NS based on a written report on the project, and on performance during the internship.
EPI7999 THÈSE DE MAÎTRISE EN ÉPIDÉMIOLOGIE / MSc THESIS IN EPIDEMIOLOGY
EPI8166 PhD SEMINAR (3cr.)
Presentation of one seminar as well as regular attendance at the departmental seminar series. Offered over two consecutive sessions. Compulsory for all students enrolled in the doctoral program in Epidemiology. Graded S/NS (Satisfactory/Not satisfactory).
EPI8566 SÉMINAIRE DE DOCTORAT (3cr.)
Présentation d’un exposé et participation régulière aux séances de séminaire du département. Offert sur deux sessions consécutives. Obligatoire pour tous les étudiants inscrits au programme de doctorat en épidémiologie. Noté S (satisfaisant) ou NS (non satisfaisant).
MED8166 PROFESSIONALISM AND PROFESSIONAL SKILLS
Basic professional skills related to academic integrity, proper referencing techniques, avoidance of plagiarism, professional etiquette, public speaking, time and stress management, conflict management, teamwork, knowing when and how to access student support services. Compulsory for all students enrolled in master’s or doctoral programs at the Faculty of Medicine. Graded S/NS (Satisfactory/Not satisfactory).
MED8167 PROFESSIONAL SKILLS (3cr.)
Professional skills related to teaching, research ethics, field work, writing, and information technology. Offered over two consecutive sessions. Compulsory for all students enrolled in the doctoral program in Epidemiology. Graded S/NS (Satisfactory/Not satisfactory). Note: Students in other Faculty of Medicine graduate programs may take this course as an additional course (above and beyond their minimum degree requirements). Graded S/NS (Satisfactory/Not satisfactory).
Corequisite: MED8166 Professionalism and Professional Skills.
MED8566 ATTITUDE ET COMPÉTENCES PROFESSIONNELLES
Compétences professionnelles de base en matière d’intégrité scolaire, d’usage des références, de vigilance face au plagiat, d’étiquette professionnelle, de présentations orales, de gestion du temps et du stress, de gestion des conflits, de travail d’équipe et de savoir faire à l’égard de l’accès aux services d’appui aux étudiants. Obligatoire pour tous les étudiants inscrits aux programmes de maîtrise ou de doctorat de la Faculté de médecine. Noté S (satisfaisant) ou NS (non satisfaisant).
MED8567 COMPÉTENCES PROFESSIONNELLES (3cr.)
Compétences professionnelles en matière d’enseignement, d’éthique de la recherche, de travail sur le terrain, de rédaction ainsi que de technologie de l’information. Offert sur deux sessions consécutives. Obligatoire pour tous les étudiants inscrits au programme de doctorat en épidémiologie. Noté S (satisfaisant) ou NS (non satisfaisant). Note : Ce cours peut être suivi à titre de cours additionnel par les étudiants dans d’autres programmes d’études supérieures en médecine (au-delà des exigences minimales de leur programme). Noté S (satisfaisant) ou NS (non satisfaisant).
Corequis : MED8566 Attitude et compétences professionnelles.
EPI9997 PROJET DE THÈSE / THESIS PROPOSAL
EPI9998 EXAMEN DE SYNTHÈSE / COMPREHENSIVE EXAMINATION
EPI9999 THÈSE DE DOCTORAT / PhD THESIS